NCLEX Question for BRCA1 cancer-predisposing gene mutation

NCLEX Review Question
A specific BRCA1 cancer-predisposing gene mutation seems to occur more frequently among women of which descent?

a.Ashkenazi Jewish
b.Mediterranean
c.African American
d.Chinese and Japanese

Correct Answer: A
Ashkenazi Jewish
Rationale: Expression of the BRCA1 gene is an example of inheritance in the development of breast cancer.

Mediterranean
Rationale: Glucose-6-phosphate dehydrogenase deficiency (G6PD) is a common enzyme abnormality that affects millions of people throughout the world, especially those of Mediterranean, South East Asian, African, Middle Eastern, and Near Eastern origin.

African American
Rationale: Sickle cell anemia is associated with the African-American population.

Chinese and Japanese
Rationale: Individuals of Chinese and Japanese descent who are rapid metabolizers of the enzyme N-acetyltransferase and who are prescribed the drug isoniazid (as part of treatment for tuberculosis) are at significantly increased risk for developing isoniazid-induced hepatitis.

Posted in: MSN NCLEX